{"id":4781,"date":"2024-12-04T11:34:50","date_gmt":"2024-12-04T03:34:50","guid":{"rendered":"https:\/\/www.bdma.com.cn\/?p=4781"},"modified":"2024-12-04T11:34:50","modified_gmt":"2024-12-04T03:34:50","slug":"%e5%8c%96%e5%ad%a6%e4%b8%93%e4%b8%9a%e5%bf%85%e6%87%82%e7%9a%84%e5%87%a0%e4%b8%aa%e6%9c%89%e6%9c%ba%e5%8f%8d%e5%ba%94%e6%9c%ba%e7%90%86%ef%bc%882%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.bdma.com.cn\/archives\/4781","title":{"rendered":"\u5316\u5b66\u4e13\u4e1a\u5fc5\u61c2\u7684\u51e0\u4e2a\u6709\u673a\u53cd\u5e94\u673a\u7406\uff082\uff09"},"content":{"rendered":"

\u5316\u5b66\u4e13\u4e1a\u5fc5\u61c2\u7684\u51e0\u4e2a\u6709\u673a\u53cd\u5e94\u673a\u7406<\/strong><\/a><\/p>\n

\u4e8c\u5143\u7fa7\u9178\u916f\u7684\u5206\u5b50\u5185\u916f\u7f29\u5408\u89c1Dieckmann\u7f29\u5408\u53cd\u5e94\u3002<\/p>\n

\u53cd\u5e94\u673a\u7406<\/p>\n

\u03b1-\u6c22\u9178\u6027\u5f88\u5f31\uff08pKa-24.5),\u800c\u94a0\u53c8\u662f\u4e00\u4e2a\u76f8\u5bf9\u8f83\u5f31\u7684\u78b1\uff08pKa~15.9\uff09\uff0c\u56e0\u6b64\uff0c\u4e0e\u94a0\u4f5c\u7528\u6240\u5f62\u6210\u7684\u8d1f\u79bb\u5b50\u5728\u5e73\u8861\u4f53\u7cfb\u662f\u5f88\u5c11\u7684\u3002\u4f46\u7531\u4e8e\u4ea7\u7269\u4e59\u9170\u662f\u4e00\u4e2a\u6bd4\u8f83\u5f3a\u7684\u9178\uff0c\u80fd\u4e0e\u94a0\u4f5c\u7528\u5f62\u6210\u7a33\u5b9a\u7684\u8d1f\u79bb\u5b50\uff0c\u4ece\u800c\u4f7f\u5e73\u8861\u671d\u4ea7\u7269\u65b9\u5411\u79fb\u52a8\u3002\u6240\u4ee5\uff0c\u5c3d\u7ba1\u53cd\u5e94\u4f53\u7cfb\u4e2d\u7684\u8d1f\u79bb\u5b50\u6d53\u5ea6\u5f88\u4f4e\uff0c\u4f46\u4e00\u5f62\u6210\u540e\uff0c\u5c31\u4e0d\u65ad\u5730\u53cd\u5e94\uff0c\u7ed3\u679c\u53cd\u5e94\u8fd8\u662f\u53ef\u4ee5\u987a\u5229\u5b8c\u6210\u3002<\/p>\n

\u5e38\u7528\u7684\u78b1\u6027\u7f29\u5408\u5242\u9664\u94a0\u5916\uff0c\u8fd8\u6709\u53d4\u4e01\u9187\u94be\u3001\u53d4\u4e01\u9187\u94a0\u3001\u6c22\u5316\u94be\u3001\u6c22\u5316\u94a0\u3001\u4e09\u82ef\u7532\u57fa\u94a0\u3001\u4e8c\u5f02\u4e19\u6c28\u57fa\u9502\uff08LDA)\u548cGrignard\u8bd5\u5242\u7b49\u3002<\/p>\n

\u4e24\u79cd\u4e0d\u540c\u7684\u916f\u4e5f\u80fd\u53d1\u751f\u916f\u7f29\u5408\uff0c\u7406\u8bba\u4e0a\u53ef\u5f97\u5230\u56db\u79cd\u4e0d\u540c\u7684\u4ea7\u7269\uff0c\u79f0\u4e3a\u6df7\u5408\u916f\u7f29\u5408\uff0c\u5728\u5236\u5907\u4e0a\u6ca1\u6709\u592a\u5927\u610f\u4e49\u3002\u5982\u679c\u5176\u4e2d\u4e00\u4e2a\u916f\u5206\u5b50\u4e2d\u65e2\u65e0\u03b1-\u6c22\u539f\u5b50\uff0c\u800c\u4e14\u70f7\u6c27\u7fb0\u57fa\u53c8\u6bd4\u8f83\u6d3b\u6cfc\u65f6\uff0c\u5219\u4ec5\u751f\u6210\u4e00\u79cd\u7f29\u5408\u4ea7\u7269\u3002\u5982\u82ef\u7532\u9178\u916f\u3001\u7532\u9178\u916f\u3001\u8349\u9178\u916f\u3001\u78b3\u9178\u916f\u7b49\u3002\u4e0e\u5176\u5b83\u542b\u03b1-\u6c22\u539f\u5b50\u7684\u916f\u53cd\u5e94\u65f6\uff0c\u90fd\u53ea\u751f\u6210\u4e00\u79cd\u7f29\u5408\u4ea7\u7269\u3002<\/p>\n

\"\u5316\u5b66\u4e13\u4e1a\u5fc5\u61c2\u7684\u51e0\u4e2a\u6709\u673a\u53cd\u5e94\u673a\u7406\uff082\uff09\u63d2\u56fe\"<\/p>\n

\u5b9e\u9645\u4e0a\u8fd9\u4e2a\u53cd\u5e94\u4e0d\u9650\u4e8e\u916f\u7c7b\u81ea\u8eab\u7684\u7f29\u5408\uff0c\u916f\u4e0e\u542b\u6d3b\u6cfc\u4e9a\u7532\u57fa\u7684\u5316\u5408\u7269\u90fd\u53ef\u4ee5\u53d1\u751f\u8fd9\u6837\u7684\u7f29\u5408\u53cd\u5e94\uff0c\u8fd9\u4e2a\u53cd\u5e94\u53ef\u4ee5\u7528\u4e0b\u5217\u901a\u5f0f\u8868\u793a\uff1a<\/p>\n

Claisen\u2014Schmidt<\/p>\n

\u4e00\u4e2a\u65e0\u03b1-\u6c22\u539f\u5b50\u7684\u919b\u4e0e\u4e00\u4e2a\u5e26\u6709\u03b1-\u6c22\u539f\u5b50\u7684\u8102\u80aa\u65cf\u919b\u6216\u916e\u5728\u7a00\u6c22\u6c27\u5316\u94a0\u6c34\u6eb6\u6db2\u6216\u9187\u6eb6\u6db2\u5b58\u5728\u4e0b\u53d1\u751f\u7f29\u5408\u53cd\u5e94,\u5e76\u5931\u6c34\u5f97\u5230\u03b1\uff0c\u03b2-\u4e0d\u9971\u548c\u919b\u6216\u916e:<\/p>\n

\u53cd\u5e94\u673a\u7406<\/p>\n

\"\u5316\u5b66\u4e13\u4e1a\u5fc5\u61c2\u7684\u51e0\u4e2a\u6709\u673a\u53cd\u5e94\u673a\u7406\uff082\uff09\u63d2\u56fe1\"<\/p>\n

\u53cd\u5e94\u5b9e\u4f8b<\/p>\n

Claisen \u91cd\u6392<\/p>\n

\u70ef\u4e19\u57fa\u82b3\u57fa\u919a\u5728\u9ad8\u6e29(200\u00b0C)\u4e0b\u53ef\u4ee5\u91cd\u6392\uff0c\u751f\u6210\u70ef\u4e19\u57fa\u915a\u3002<\/p>\n

\u5f53\u70ef\u4e19\u57fa\u82b3\u57fa\u919a\u7684\u4e24\u4e2a\u90bb\u4f4d\u672a\u88ab\u53d6\u4ee3\u57fa\u5360\u6ee1\u65f6\uff0c\u91cd\u6392\u4e3b\u8981\u5f97\u5230\u90bb\u4f4d\u4ea7\u7269\uff0c\u4e24\u4e2a\u90bb\u4f4d\u5747\u88ab\u53d6\u4ee3\u57fa\u5360\u636e\u65f6\uff0c\u91cd\u6392\u5f97\u5230\u5bf9\u4f4d\u4ea7\u7269\u3002\u5bf9\u4f4d\u3001\u90bb\u4f4d\u5747\u88ab\u5360\u6ee1\u65f6\u4e0d\u53d1\u751f\u6b64\u7c7b\u91cd\u6392\u53cd\u5e94\u3002<\/p>\n

\u4ea4\u53c9\u53cd\u5e94\u5b9e\u9a8c\u8bc1\u660e\uff1aClaisen\u91cd\u6392\u662f\u5206\u5b50\u5185\u7684\u91cd\u6392\u3002\u91c7\u7528 g-\u78b3 14C\u6807\u8bb0\u7684\u70ef\u4e19\u57fa\u919a\u8fdb\u884c\u91cd\u6392\uff0c\u91cd\u6392\u540e g-\u78b3\u539f\u5b50\u4e0e\u82ef\u73af\u76f8\u8fde\uff0c\u78b3\u78b3\u53cc\u952e\u53d1\u751f\u4f4d\u79fb\u3002\u4e24\u4e2a\u90bb\u4f4d\u90fd\u88ab\u53d6\u4ee3\u7684\u82b3\u57fa\u70ef\u4e19\u57fa\u915a\uff0c\u91cd\u6392\u540e\u5219\u4ecd\u662fa-\u78b3\u539f\u5b50\u4e0e\u82ef\u73af\u76f8\u8fde\u3002<\/p>\n

\"\u5316\u5b66\u4e13\u4e1a\u5fc5\u61c2\u7684\u51e0\u4e2a\u6709\u673a\u53cd\u5e94\u673a\u7406\uff082\uff09\u63d2\u56fe2\"<\/p>\n

\u53cd\u5e94\u673a\u7406<\/p>\n

Claisen \u91cd\u6392\u662f\u4e2a\u534f\u540c\u53cd\u5e94\uff0c\u4e2d\u95f4\u7ecf\u8fc7\u4e00\u4e2a\u73af\u72b6\u8fc7\u6e21\u6001\uff0c\u6240\u4ee5\u82b3\u73af\u4e0a\u53d6\u4ee3\u57fa\u7684\u7535\u5b50\u6548\u5e94\u5bf9\u91cd\u6392\u65e0\u5f71\u54cd\u3002<\/p>\n

\u4ece\u70ef\u4e19\u57fa\u82b3\u57fa\u919a\u91cd\u6392\u4e3a\u90bb\u70ef\u4e19\u57fa\u915a\u7ecf\u8fc7\u4e00\u6b21[3,3]s\u8fc1\u79fb\u548c\u4e00\u6b21\u7531\u916e\u5f0f\u5230\u70ef\u9187\u5f0f\u7684\u4e92\u53d8\u5f02\u6784\uff1b\u4e24\u4e2a\u90bb\u4f4d\u90fd\u88ab\u53d6\u4ee3\u57fa\u5360\u636e\u7684\u70ef\u4e19\u57fa\u82b3\u57fa\u915a\u91cd\u6392\u65f6\u5148\u7ecf\u8fc7\u4e00\u6b21[3,3]s \u8fc1\u79fb\u5230\u90bb\u4f4d(Claisen \u91cd\u6392)\uff0c\u7531\u4e8e\u90bb\u4f4d\u5df2\u88ab\u53d6\u4ee3\u57fa\u5360\u636e\uff0c\u65e0\u6cd5\u53d1\u751f\u4e92\u53d8\u5f02\u6784\uff0c\u63a5\u7740\u53c8\u53d1\u751f\u4e00\u6b21[3,3]s \u8fc1\u79fb(Cope\u91cd\u6392)\u5230\u5bf9\u4f4d\uff0c\u7136\u540e\u7ecf\u4e92\u53d8\u5f02\u6784\u5f97\u5230\u5bf9\u4f4d\u70ef\u4e19\u57fa\u915a\u3002<\/p>\n

\u53d6\u4ee3\u7684\u70ef\u4e19\u57fa\u82b3\u57fa\u919a\u91cd\u6392\u65f6\uff0c\u65e0\u8bba\u539f\u6765\u7684\u70ef\u4e19\u57fa\u53cc\u952e\u662fZ-\u6784\u578b\u8fd8\u662fE-\u6784\u578b\uff0c\u91cd\u6392\u540e\u7684\u65b0\u53cc\u952e\u7684\u6784\u578b\u90fd\u662fE-\u578b\uff08\u53cd\u5f0f\uff09\uff0c\u8fd9\u662f\u56e0\u4e3a\u91cd\u6392\u53cd\u5e94\u6240\u7ecf\u8fc7\u7684\u516d\u5458\u73af\u72b6\u8fc7\u6e21\u6001\u5177\u6709\u7a33\u5b9a\u6905\u5f0f\u6784\u8c61\u7684\u7f18\u6545\u3002<\/p>\n

Claisen \u91cd\u6392\u5177\u6709\u666e\u904d\u6027\uff0c\u5728\u919a\u7c7b\u5316\u5408\u7269\u4e2d\uff0c\u5982\u679c\u5b58\u5728\u70ef\u4e19\u6c27\u57fa\u4e0e\u78b3\u78b3\u76f8\u8fde\u7684\u7ed3\u6784\uff0c\u5c31\u6709\u53ef\u80fd\u53d1\u751fClaisen \u91cd\u6392\u3002<\/p>\n

Favorskii \u91cd\u6392<\/p>\n

a-\u5364\u4ee3\u916e\u5728\u6c22\u6c27\u5316\u94a0\u6c34\u6eb6\u6db2\u4e2d\u52a0\u70ed\u91cd\u6392\u751f\u6210\u542b\u76f8\u540c\u78b3\u539f\u5b50\u6570\u7684\u7fa7\u9178\uff1b\u5982\u4e3a\u73af\u72b6a-\u5364\u4ee3\u916e\uff0c\u5219\u5bfc\u81f4\u73af\u7f29\u5c0f\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5316\u5b66\u4e13\u4e1a\u5fc5\u61c2\u7684\u51e0\u4e2a\u6709\u673a\u53cd\u5e94\u673a\u7406 \u4e8c\u5143\u7fa7\u9178\u916f\u7684\u5206\u5b50\u5185\u916f\u7f29\u5408\u89c1Dieckmann\u7f29\u5408\u53cd\u5e94\u3002 \u53cd\u5e94\u673a\u7406 \u03b1-\u6c22\u9178\u6027\u5f88\u5f31\uff08pKa-24.5),\u800c\u94a0\u53c8\u662f\u4e00\u4e2a\u76f8\u5bf9\u8f83\u5f31\u7684\u78b1\uff08pKa~15.9\uff09\uff0c\u56e0\u6b64\uff0c\u4e0e\u94a0\u4f5c\u7528\u6240\u5f62\u6210… <\/p>\n","protected":false},"author":2,"featured_media":4782,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[45],"tags":[],"_links":{"self":[{"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/posts\/4781"}],"collection":[{"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/comments?post=4781"}],"version-history":[{"count":1,"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/posts\/4781\/revisions"}],"predecessor-version":[{"id":4785,"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/posts\/4781\/revisions\/4785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/media\/4782"}],"wp:attachment":[{"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/media?parent=4781"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/categories?post=4781"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bdma.com.cn\/wp-json\/wp\/v2\/tags?post=4781"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}